How to read the lists
Each list is in alphabetical order of the code, not of the city. If you know the city and not the code, use the search box on the home page instead.
Do the letters mean anything?
The first letter of an IATA code has no fixed meaning. Codes are given out one by one, usually to match the city or airport name. Two patterns are worth knowing: many Canadian airports start with Y, such as YYZ for Toronto, and a few big cities have a code for the whole city next to the codes of their airports, such as LON for London and NYC for New York.